Network property of CRE co-occurrence networks and clique-clique networks of the input gene-sets.

The coefficient of assortativity (r) reflects the assortative mixing topology of a network. Negative values of r of the CRE co-occurrence networks indicate their disassortative mixing topology whereas, positive values of r observed in clique-clique networks imply their assortative mixing topology. Further, the network clustering coefficient (C‾) values of the clique-clique networks are significantly higher than their respective CRE co-occurrence networks and this global attribute is an indicator of cohesiveness of the clique-clique networks. Significance is tested by permutation Mann-Whitney U test (No. of permutation = 10000), p