Ischemia-preconditioning induced serum exosomal miR-133a-3p improved post-myocardial infarction repair via targeting LTBP1/TGF-β1/PPP2CA axis. Ischemia-preconditioning induced serum exosomal miR-133a-3p improved post-myocardial infarction repair via targeting LTBP1/TGF-β1/PPP2CA axis

This study found that IPC-induced serum exosomes inhibit myocardial fibrosis and improve cardiac function following MI by transferring miR-133a-3p, which targets LTBP1 and PPP2CA, to regulate the TGF-β signaling pathway in rats. Overall design: Exosomes were obtained from the serum of adult rats in the control (Con-exo) and IPC (IPC-exo) groups. The samples for high -throughput sequencing were three in each group.