Structure of human protein kinase CK2 catalytic subunit (CK2alpha, CSNK2A1 gene product) in complex with the cyclic peptidomimetic compound 12 discovered by high-throughput screening

Structure of human protein kinase CK2 catalytic subunit (CK2alpha, CSNK2A1 gene product) in complex with the cyclic peptidomimetic compound 12 discovered by high-throughput screening Descriptor: Casein kinase II subunit alpha, Cyclic peptidomimetic compound FMP37, NICOTINIC ACID, ... Authors: Werner, C, Niefind, K, Pietsch, M, Eimermacher, S, Lindenblatt, D. Deposit date: 2024-05-14 Release date: 2025-06-11 Last modified: 2026-07-01 Method: X-RAY DIFFRACTION (2.054 Å) Cite: Discovery and characterization of a novel class of cyclic peptidic compounds inhibiting the subunit interaction of the protein kinase CK2 alpha 2 beta 2 holoenzyme Rsc Chem Biol, 2026经高通量筛选发现的环状拟肽化合物12与人类蛋白激酶CK2催化亚基（CK2α，CSNK2A1基因编码产物）形成的复合物结构。描述词：酪蛋白激酶II亚基α、环状拟肽化合物FMP37、烟酸……。作者：Werner C、Niefind K、Pietsch M、Eimermacher S、Lindenblatt D。存档日期：2024年5月14日；发布日期：2025年6月11日；最后修改日期：2025年11月5日。实验方法：X射线衍射（2.054埃）。引用文献：《一类可抑制蛋白激酶CK2α₂/β₂全酶组装的新型环状肽类化合物的发现与表征》（待发表）