c-Myc supports polyploidy and prevents senescence in the murine placenta
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2023-06-30
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Sex-specific results of the DESeq2 differential expression analysis of mouse placental tissue show sex-specific expression after adjusting for developmental light treatment and first surrogate variable.
Male placenta tissue is the reference, so results show genes that are upregulated (postive log2FoldChange) or downregulated (negative log2FoldChange) in female placenta tissue. To control for false di
NIAID Data Ecosystem70
Design, Synthesis, and Evaluation of New Selective NM23-H2 Binders as c‑MYC Transcription Inhibitors via Disruption of the NM23-H2/G-Quadruplex Interaction
c-MYC is one of the important human proto-oncogenes, and transcriptional factor NM23-H2 can activate c-MYC transcription by recognizing the G-quadruplex in the promoter of the gene. Small molecules th
NIAID Data Ecosystem60
Table_2_S100P promotes trophoblast syncytialization during early placenta development by regulating YAP1.docx
Recurrent pregnancy loss (RPL) is a severe complication of pregnancy that is caused by genetic abnormalities, immune dysfunction, aberrant cell biology, and tissue structure destruction. Among which,
NIAID Data Ecosystem30
Single-cell atlas of patient-derived trophoblast organoids (TO) in on-going pregnancies.. Single-cell atlas of patient-derived trophoblast organoids (TO) in on-going pregnancies.
Trophoblast organoids (TOs) hold great promise for elucidating human placental development and function. By deriving TOs in on-going pregnancies using chorionic villus sampling (CVS), we established a
NIAID Data Ecosystem60
Effect of depletion of TET3 on gene expression of HTR8-SVneo trophoblast cells.
To investigate the function TET3 in the regulation of DNA methylation, we established HTR8-SVneo cell lines in which target gene has been knocked down by siRNA. We then performed gene expression profi
NIAID Data Ecosystem50
