Comprehensive Evaluation of Human Brain Gene Expression Deconvolution Methods

We benchmarked deconvolution algorithms on human brain gene expression data. The data deposited here include A) mixtures on which algorithms were benchmarked, as well as B) signatures of pure brain cell-type expression 5 RNA-seq samples generated from mixtures of cultured neuronal and astrocyte RNA (neuronal:astrocyte RNA ratios of 0:100,40:60,45:55,50:50, and 100:0). 10 RNA-seq samples of paired cytoplasmic and nuclear preparations from 5 bulk adult human brain tissue samples.