Differential Expression of NPAS4 in the Dorsolateral Prefrontal Cortex Following Opioid Overdose

The goals of the present study were to compare gene expression in the prefrontal cortex between brain samples of individuals who died of acute opioid intoxication and group-matched controls, and to test if differential gene expression was enriched in gene sets related to opioid use. This study advances our understanding of the neurobiological consequences of opioid abuse.