Transcriptomic analysis of lung adenocarcinomas from KP and KPCic mice

The transcriptional repressor Capicua (CIC) is negatively regulated by KRAS/MAPK signaling. To characterize the impact of CIC loss on KrasG12V/Trp53-KO-driven lung adenocarcinomas in mice, the transcriptome of tumors from Kras (+/LSLG12V); Trp53 (lox/lox) [KP] and Kras (+/LSLG12V); Trp53 (lox/lox); Cic (lox/lox) [KPCic] mice are compared. Overall design: RNA-seq profiling of lung adenocarcinomas from KP and KPCic mice obtained 5 months after infection with Adeno-Cre.