Decoupling Lineage-Associated Genes in Acute Myeloid Leukemia Reveals Inflammatory and Metabolic Signatures Associated with Outcomes

AML is a heterogeneous disease with current genomic and cytogenetic based classifications do not fully account for patient-to-patient variability. By decoupling lineage-related changes from transcriptomic signatures and integrating orthogonal genomic and proteomic based assays, we uncovered AML group of patients with inflammatory and metabolic signatures that inform outcomes. Overall design: Assessment of newly diagnosed AML patients