Blood–brain barrier (BBB) dysfunction causing edema and hemorrhagic transformation is one of the pathophysiological characteristics of stroke. Protection of BBB integrity has shown great potential in
Neuroprotective strategies aimed to pharmacologically treat stroke, a prominent cause of death, disability and dementia, have remained elusive. A promising approach is restriction of excitotoxic neuro
Estrogen reduces brain injury after experimental cerebral ischemia in part through a genomic mechanism of action. Using DNA microarrays, we analyzed the genomic response of the brain to estradiol, and