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miRNA-seq data from healthy and DMD human cells, along skeletal muscle differentiation from induced pluripotent stem cells

ChEBI2020-10-05 更新2026-07-12 收录

杜氏肌营养不良症分子机制

干细胞骨骼肌分化

数据链接：

https://www.ebi.ac.uk/biostudies/ArrayExpress/studies/E-MTAB-8293 数据链接链接失效反馈

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miRNA-seq data from healthy and DMD human cells, along skeletal muscle differentiation from induced pluripotent stem cells

应用场景：

创建时间：

2020-10-05

杜氏肌营养不良症分子机制

肌成纤维细胞基因表达

Duchenne muscular dystrophy (DMD) is a severely debilitating and incurable neuromuscular disease. Its conspicuous feature is the absence of dystrophin in myofibers and therefore most therapeutic appro

NIAID Data Ecosystem70

Small RNA Seq of DMD muscle biopsies identifies a miRNA signature associated with fibrotic status. Small RNA Seq of DMD muscle biopsies identifies a miRNA signature associated with fibrotic status

杜氏肌营养不良症分子机制

纤维化调控

Fibrosis is a deleterious invasion of tissues associated with many pathological conditions, such as Duchenne muscular dystrophy (DMD) for which no cure is at present available for its prevention or it

NIAID Data Ecosystem50

Novel Approach to Meta-Analysis of Microarray Datasets Reveals Muscle Remodeling-related Drug Targets and Biomarkers in Duchenne Muscular Dystrophy

杜氏肌营养不良症分子机制

药物靶点发现

Elucidation of new biomarkers and potential drug targets from high-throughput profiling data is a challenging task due to a limited number of available biological samples and questionable reproducibil

NIAID Data Ecosystem20

Defining the skeletal myogenic lineage in human pluripotent stem cell-derived teratomas

干细胞骨骼肌分化

单细胞转录组学

Skeletal muscle stem cells are essential to muscle homeostasis and regeneration after injury. An attractive approach to obtain these cells is via differentiation of pluripotent stem cells (PSCs). We h

NIAID Data Ecosystem50

A novel CRISPR-Cas9 strategy to target DYSTROPHIN mutations downstream of exon 44 in patient-specific DMD iPSCs

基因治疗研究

杜氏肌营养不良症分子机制

Here, we performed CRISPR-cas9 mediated genetic correction in DMD patient derived iPSC and then differentiated them into in vitro myotubes. Pairing bulk RNA sequencing between Wild-type (WT), DMD an

NIAID Data Ecosystem40

miRNA-seq data from healthy and DMD human cells, along skeletal muscle differentiation from induced pluripotent stem cells

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