Runx1 downregulates stem cell and megakaryocytic transcription programs that support niche interactions

ChEBI2016-07-01 更新2026-07-12 收录

造血干细胞调控

巨核细胞转录组学

数据链接：

https://www.ebi.ac.uk/biostudies/ArrayExpress/studies/E-GEOD-81182 数据链接链接失效反馈

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Runx1 downregulates stem cell and megakaryocytic transcription programs that support niche interactions

创建时间：

2016-07-01

Convergence of Hypoxia and TGFβ Pathways on Cell Cycle Regulation in Human Hematopoietic Stem/Progenitor Cells

造血干细胞调控

缺氧响应机制

Although it has been shown that HIF1 and 2 fulfill essential roles within the hematopoietic system and in the regulation of HSC fate, little is currently known about the specific mechanisms that are i

NIAID Data Ecosystem50

A genetic disorder reveals a hematopoietic stem cell regulatory network co-opted in leukemia [amplicon-seq]

造血干细胞调控

白血病分子机制

we uncover a key transcriptional network involving hundreds of genes that is required for HSC self-renewal. Overall design: MECOM impact on the hematopoietic stem cells

NIAID Data Ecosystem20

Inhibition of DEK contributes to the tolerance of replication stress and restores HSC function in Fanconi anemia (8-ATAC). Inhibition of DEK contributes to the tolerance of replication stress and restores HSC function in Fanconi anemia (8-ATAC)

范可尼贫血分子机制

造血干细胞调控

Replication stress drives functional decline in HSCs and is a major driver of BM failure in Fanconi anemia (FA). At present, how HSCs respond and counteract replication stress remains largely unknown.

NIAID Data Ecosystem10

Musashi 2 is a regulator of the hematopoietic stem cell compartment identified by a retroviral insertion screen and knockout mice

造血干细胞调控

基因功能研究

Musashi 2 is a regulator of the hematopoietic stem cell compartment identified by a retroviral insertion screen and knockout mice

ChEBI2011-05-21 更新20

Maintenance of haematopoietic stem cells by tyrosine-unphosphorylated STAT5 and JAK inhibition - STAT5 deficient HSPCs (LK). Maintenance of haematopoietic stem cells by tyrosine-unphosphorylated STAT5 and JAK inhibition - STAT5 deficient HSPCs (LK)

造血干细胞调控

JAK-STAT信号通路

Adult haematopoietic stem cells (HSCs) are responsible for the lifelong production of blood and immune cells and must respond to extracellular cues including cytokines. The JAK/STAT pathway is a highl

NIAID Data Ecosystem20

Runx1 downregulates stem cell and megakaryocytic transcription programs that support niche interactions

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