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SWI/SNF Chromatin Remodeling Factor BRG1 is Synthetic Required for PTEN-deficient Prostate Cancer

NIAID Data Ecosystem2026-03-11 收录

前列腺癌合成致死

染色质重塑与肿瘤

数据链接：

https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE115619 数据链接链接失效反馈

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资源简介：

This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

应用场景：

创建时间：

2019-03-26

脑肿瘤分子机制

染色质重塑与肿瘤

This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

NIAID Data Ecosystem70

Histone chaperone CAF-1 is a synthetic lethal vulnerability in the context of ARID1A deficiencies [ATAC-Seq]

染色质重塑与肿瘤

合成致死治疗

Mutations in the BAF chromatin remodeling complex rank among the most frequent genetic alterations in human cancers, many of which result in a loss of function of the respective subunits. Recent genom

NIAID Data Ecosystem50

FOXA2 suppresses endometrial carcinogenesis and epithelial-mesenchymal transition through its actions as chromatin remodeler [WT106]

子宫内膜癌分子机制

染色质重塑与肿瘤

FOXA2 encodes a transcription factor mutated in 10% of endometrial cancers (ECs), with a higher mutation rate in aggressive variants. FOXA2 has essential roles in embryonic and uterine development. Ho

NIAID Data Ecosystem50

Reconstructing gene regulatory networks of tumorigenesis [ChIP-Seq]

肿瘤基因调控

染色质重塑与肿瘤

The mechanistic links between transcription factors and the epigenetic landscape, which coordinate the deregulation of gene networks during cell transformation are largely unknown. We used an isogenic

NIAID Data Ecosystem70

ARID2 promotes clear cell renal cell carcinoma in the absence of functional PBRM1 [microarray]

肾透明细胞癌分子机制

染色质重塑与肿瘤

Subunits of SWI/SNF chromatin remodeling complexes are frequently mutated in human malignancies. The PBAF complex is composed of multiple subunits, including the putative tumor suppressor proteins PBR

NIAID Data Ecosystem50

SWI/SNF Chromatin Remodeling Factor BRG1 is Synthetic Required for PTEN-deficient Prostate Cancer

资源简介：

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