Release of Human Cytomegalovirus from latency by a KAP1/TRIM28 phosphorylation switch
收藏NIAID Data Ecosystem2026-03-11 收录
下载链接：
https://www.ncbi.nlm.nih.gov/sra/SRP034016
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资源简介：
A new actor of HCMV latency is unveiled, where KAP1 protein binds to viral genome to recruit SetDB1 and trigger H3K9 trimethylation. A switch of phosphorylation state mediated by mTOR leads to lytic replication, opening new approaches to curtail CMV infection but also to purge the virus from organ transplants. Overall design: Analyses of transcriptional profiles and chromatin state in KAP1 WT and KO (or KD) cells
创建时间：
2019-09-24
