Prevalent pemivibart escape constellations in global SARS-CoV-2 genomes (R346T, K444T, F456L, F486P)

PEMIVIBART ESCAPE MUTATION SUMMARY (2022 till 2024) (Early Chunk)============================================================ Input file: D:\tahirhb\pemivibart_escape_mutations.csvReport generated: pemivibart_escape_summary.py Total sequences with ≥1 escape mutation: 33,372Total escape mutation events detected: 60,709 Mutation counts (Wuhan-Hu-1 numbering): F456L: 8,631 R346T: 24,943 K444T: 7,860 F486P: 19,275 Sequences by number of escape mutations: 1 mutation: 11,935 2 mutations: 15,567 3 mutations: 5,840 4 mutations: 30 Top 10 sequences with most escape mutations: 1. USA/PR-CVL-022162/2024 → 4 mutations: F456L, F486P, K444T, R346T 2. USA/NMDOH-2023049605/2023 → 4 mutations: F456L, F486P, K444T, R346T 3. USA/NMDOH-2024010914/2024 → 4 mutations: F456L, F486P, K444T, R346T 4. USA/NY-PRL-231130_83E05/2023 → 4 mutations: F456L, F486P, K444T, R346T 5. USA/MN-MDH-38077/2023 → 4 mutations: F456L, F486P, K444T, R346T 6. USA/CO-CDPHE-41525514/2023 → 4 mutations: F456L, F486P, K444T, R346T 7. USA/CO-CDPHE-41556934/2023 → 4 mutations: F456L, F486P, K444T, R346T 8. USA/NJ-CDC-LC1073612/2023 → 4 mutations: F456L, F486P, K444T, R346T 9. USA/CO-CDPHE-41491811/2023 → 4 mutations: F456L, F486P, K444T, R346T 10. Denmark/DCGC-660941/2023 → 4 mutations: F456L, F486P, K444T, R346T Interpretation:- Sequences with ≥2 mutations (e.g., F456L + R346T) are likely LP.8.1-like- Expected IC50 > 0.0189 µg/mL (probable)- F486P is rare but high-impact (predicted IC50 >> 0.04 µg/mL)-------------------------------------Early chunk of the bulk summary-------------------------------------