Gut microbiota analysis associated with hepatocellular carcinoma

Here we report 16s rRNA data in gut microbiota of hepatocellular carcinoma (HCC) patients with HBV induced HCC (HBVC) and non-HBV induced HCC (NHBVC) compared with healthy volunteers. A total of 2047 operational taxonomic units (OTUs) were identified in the sequence data. Our data shows that the NHBVC patients harbor lower anti-inflammatory bacteria and more pro-inflammatory bacteria, while the HBVC patients harbor more anti-inflammatory bacteria. Microbial DNA from fecal samples [healthy control (n=33), NHBVC patients (n=26), HBVC (n=35) was amplified by PCR using universal bacterial primers, and 16S rRNA genes were pyrosequenced.