Identification of Amides Derived From 1H-Pyrazolo[3,4-b]pyridine-5-carboxylic Acid as Potent Inhibitors of Human Nicotinamide Phosphoribosyltransferase (NAMPT)

Identification of Amides Derived From 1H-Pyrazolo[3,4-b]pyridine-5-carboxylic Acid as Potent Inhibitors of Human Nicotinamide Phosphoribosyltransferase (NAMPT) Descriptor: 1-(5-O-phosphono-beta-D-ribofuranosyl)-N-(4-{[3-(trifluoromethyl)phenyl]sulfonyl}benzyl)-1H-pyrazolo[3,4-b]pyridine-5-carboxamide, Nicotinamide phosphoribosyltransferase, PHOSPHATE ION, ... Authors: Giannetti, A.M, Zheng, X, Skelton, N, Wang, W, Bravo, B, Feng, Y, Gunzner-Toste, J, Ho, Y, Hua, R, Wang, C, Zhao, Q, Liederer, B.M, Liu, Y, O'Brien, T, Oeh, J, Sampath, D, Shen, Y, Wang, L, Wu, H, Xiao, Y, Yuen, P, Zak, M, Zhao, G, Dragovich, P.S. Deposit date: 2013-08-10 Release date: 2013-09-25 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (2.406 Å) Cite: Identification of amides derived from 1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid as potent inhibitors of human nicotinamide phosphoribosyltransferase (NAMPT). Bioorg.Med.Chem.Lett., 23, 2013

1H-吡唑并[3,4-b]吡啶-5-羧酸衍生酰胺作为人烟酰胺磷酸核糖转移酶（Nicotinamide Phosphoribosyltransferase, NAMPT）强效抑制剂的发现
描述物：1-(5-O-磷酸-β-D-呋喃核糖基)-N-(4-{[3-(三氟甲基)苯基]磺酰基}苄基)-1H-吡唑并[3,4-b]吡啶-5-甲酰胺、烟酰胺磷酸核糖转移酶、磷酸根离子等
作者：Giannetti, A.M、Zheng, X、Skelton, N、Wang, W、Bravo, B、Feng, Y、Gunzner-Toste, J、Ho, Y、Hua, R、Wang, C、Zhao, Q、Liederer, B.M、Liu, Y、O'Brien, T、Oeh, J、Sampath, D、Shen, Y、Wang, L、Wu, H、Xiao, Y、Yuen, P、Zak, M、Zhao, G、Dragovich, P.S.
提交日期：2013-08-10
发布日期：2013-09-25
最后修改日期：2024-02-28
检测方法：X射线衍射（X-RAY DIFFRACTION），分辨率2.406埃（Å）
引用文献：1H-吡唑并[3,4-b]吡啶-5-羧酸衍生酰胺作为人烟酰胺磷酸核糖转移酶（NAMPT）强效抑制剂的发现. Bioorg.Med.Chem.Lett., 23, 2013