GRNdb

Gene regulatory networks are crucial for understanding the mechanism of gene expression regulation and expression heterogeneity. GRNdb is a freely accessible and user-friendly database for conveniently exploring and visualizing the predicted regulatory networks formed by transcription factors (TFs) and downstream target genes (termed regulons) based on large-scale RNA-seq data as well as the known TF-target relationships for various human and mouse conditions.

基因调控网络（Gene Regulatory Networks，GRN）对于解析基因表达调控机制与阐释表达异质性具有关键意义。GRNdb是一款免费开放、用户友好的数据库，可便捷地探索并可视化基于大规模RNA测序（RNA-seq）数据预测得到的、由转录因子（Transcription Factors，TFs）与下游靶基因所构成的调控网络（亦称调控子regulons），同时收录人类与小鼠多种生理条件下已知的TF-靶基因关联关系。

搜集汇总

背景与挑战

背景概述

GRNdb是一个免费、用户友好的数据库，专注于基因调控网络的研究，提供转录因子与靶基因调控关系的预测和可视化功能，基于大规模RNA-seq数据，适用于人类和小鼠的不同条件。