Graphical representation of the percentage change of characteristic MI-network parameters.

The x-axis shows nine network parameters characterizing the network structure. The ordinate shows the percentage change of the corresponding parameter when DOG feeding replaces standard diet. Note that we plot the percentage change of the reciprocal value of the network diameter, thereby ensuring that upward pointing bars consistently indicate better connectivity under DOG-treatment (compared to controls), and downward-pointing bars indicate relaxed network connectivity in the DOG-case. The colors of the bars indicate the gene set the change was recorded for: grey bars - randomly chosen “background” genes; blue bars - mTOR pathway genes; red bars - oxidative phosphorylation pathway; red bars - glutathione metabolism pathway; green bars - glycolysis pathway.