Crystal structure of 11b-HSD1 double mutant (L262R, F278E) in complex with 3-[1-(4-chlorophenyl)cyclopropyl]-8-cyclopropyl[1,2,4]triazolo[4,3-a]pyridine

Crystal structure of 11b-HSD1 double mutant (L262R, F278E) in complex with 3-[1-(4-chlorophenyl)cyclopropyl]-8-cyclopropyl[1,2,4]triazolo[4,3-a]pyridine Descriptor: 3-[1-(4-chlorophenyl)cyclopropyl]-8-cyclopropyl[1,2,4]triazolo[4,3-a]pyridine, Corticosteroid 11-beta-dehydrogenase isozyme 1, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE Authors: Sheriff, S. Deposit date: 2012-12-23 Release date: 2014-06-11 Last modified: 2024-04-03 Method: X-RAY DIFFRACTION (2.35 Å) Cite: Optimization of 1,2,4-Triazolopyridines as Inhibitors of Human 11 beta-Hydroxysteroid Dehydrogenase Type 1 (11 beta-HSD-1). ACS Med Chem Lett, 5, 2014

11β-HSD1双突变体（L262R、F278E）与3-[1-(4-氯苯基)环丙基]-8-环丙基[1,2,4]三唑并[4,3-a]吡啶的复合物晶体结构。描述项：3-[1-(4-氯苯基)环丙基]-8-环丙基[1,2,4]三唑并[4,3-a]吡啶、皮质类固醇11β-脱氢酶同工酶1（Corticosteroid 11-beta-dehydrogenase isozyme 1）以及烟酰胺腺嘌呤二核苷酸磷酸（NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE）。作者：Sheriff, S.；提交日期：2012-12-23；发布日期：2014-06-11；最后修改日期：2024-04-03。实验方法：X射线衍射（2.35 Å）。引用文献：《1,2,4-三唑并吡啶类化合物作为人类11β-羟基类固醇脱氢酶1型（11β-HSD-1）抑制剂的优化》，刊载于《ACS药物化学通讯》（ACS Med Chem Lett），2014年，第5卷。