A Comparative Environmental Assessment for the Synthesis of 1,3-Oxazin-2-one by Metrics: Greenness Evaluation and Blind Spots

Alternative syntheses for the production
of 3-benzyl-1,3-oxazinan-2-one
are compared and evaluated employing green metrics. An environmental
assessment has been performed using the algorithm recently developed
by Andraos that takes into account the mass flows and the software
EATOS that considers mass flows, environmental impacts of the substances
involved, and waste produced. Strengths and critical spots of the
environmental tools employed are also discussed. Data collected showed
that the synthesis employing diethyl carbonate is the most promising
one, having the lowest environmental impact.