Long-term Proton Pump Inhibitor Administration Caused Physiological and Microbiota Changes in Rats. Long-term Proton Pump Inhibitor Administration Caused Physiological and Microbiota Changes in Rats

Proton pump inhibitors (PPIs) are used for the long-term treatment of gastroesophageal disorders and the non-prescription medicines for acid reflux. However, there is growing concerns about PPI misuse, overuse and abuse. This study aimed to develop an animal model to examine the effects of long-term use of PPI in vivo.