Crystal Structure of HIV-1 Reverse Transcriptase in Complex with 5-(2-(2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)ethoxy)phenoxy)-7-fluoro-2-naphthonitrile (JLJ635), a Non-nucleoside Inhibitor

Crystal Structure of HIV-1 Reverse Transcriptase in Complex with 5-(2-(2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)ethoxy)phenoxy)-7-fluoro-2-naphthonitrile (JLJ635), a Non-nucleoside Inhibitor Descriptor: 5-{2-[2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)ethoxy]phenoxy}-7-fluoronaphthalene-2-carbonitrile, HIV-1 REVERSE TRANSCRIPTASE, P51 SUBUNIT, ... Authors: Bertoletti, N, Kudalkar, S.N, Anderson, K.S, Cisneros Trigo, J.A, Jorgensen, W.L. Deposit date: 2019-03-27 Release date: 2019-05-15 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (2.9 Å) Cite: Structural and pharmacological evaluation of a novel non-nucleoside reverse transcriptase inhibitor as a promising long acting nanoformulation for treating HIV. Antiviral Res., 167, 2019

结合非核苷类抑制剂（Non-nucleoside Inhibitor）JLJ635的HIV-1逆转录酶（HIV-1 Reverse Transcriptase）晶体结构
配体描述：5-{2-[2-(2,4-二氧代-3,4-二氢嘧啶-1(2H)-基)乙氧基]苯氧基}-7-氟萘-2-甲腈；研究对象：HIV-1逆转录酶、P51亚基……
作者：Bertoletti, N、Kudalkar, S.N、Anderson, K.S、Cisneros Trigo, J.A、Jorgensen, W.L
提交日期：2019-03-27
发布日期：2019-05-15
最后修改日期：2023-10-11
实验方法：X射线衍射（X-RAY DIFFRACTION），分辨率2.9 Å
引用文献：Structural and pharmacological evaluation of a novel non-nucleoside reverse transcriptase inhibitor as a promising long acting nanoformulation for treating HIV. Antiviral Res., 167, 2019