We investigated the specificity profiles of a variety of RNA guided adenosine deaminases while exploring roles of NLS/NES and hyperactive mutants via analysis of the transcriptome-wide off-target A->G

NIAID Data Ecosystem50

Binding site volumes and normalized docking scores (NDS) of CETP inhibitors for CETP and six classes of putative off-targets.

药物靶点预测

脱靶效应分析

The predicted binding affinities are grouped with different symbols: * represents strong binding affinity (NDS NDS>−2.0), and others represent less likely binding due to

NIAID Data Ecosystem20

Gene replacement of alpha-globin with beta-globin restores hemoglobin balance in beta-thalassemia-derived hematopoietic stem and progenitor cells

基因编辑治疗

脱靶效应分析

Targeted deep sequencing of top-40 predicted off-target sites for HBA1-specific 3' UTR guide RNA reported in Cromer, et al., Nature Medicine, 2021.

NIAID Data Ecosystem50

Metabolic effects of an aspartate aminotransferase-inhibitor on two T-cell lines

药物代谢组学

脱靶效应分析

An emerging method to help elucidate the mode of action of experimental drugs is to use untargeted metabolomics of cell-systems. The interpretations of such screens are however complex and more exampl

NIAID Data Ecosystem30

Specificity analysis and optimization of evoCas12f

资源简介：

相关数据集