Neural deficits in PACS1 syndrome caused by dysregulated HDAC6 are corrected with targeted therapy
收藏Figshare2023-11-17 更新2026-04-08 收录
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https://springernature.figshare.com/articles/dataset/Neural_deficits_in_PACS1_syndrome_caused_by_dysregulated_HDAC6_are_corrected_with_targeted_therapy/24199551/1
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资源简介：
PACS1 syndrome is caused by an Arg203Trp mutation in PACS1. We show PACS1R203W dysregulates HDAC6 to disturb neuronal structure and function in vivo. Silencing PACS1R203W/HDAC6 reverses these deficits, suggesting this disorder is treatable.
提供机构：
Thomas, Gary; Villar-Pazos, Sabrina; Thomas, Laurel; Yang, Yunhan
创建时间：
2023-10-19
