Mutation analysis of the CHK2 gene in breast carcinoma and other cancers

Background Mutations in the CHK2 gene at chromosome 22q12.1 have been reported in families with Li-Fraumeni syndrome. Chk2 is an effector kinase that is activated in...研究背景：位于染色体22q12.1的CHK2基因的突变已在李-弗劳梅尼综合征（Li-Fraumeni syndrome）家系中被报道。Chk2是一种效应激酶，可在……中被激活。