Vp1524, a Vibrio parahaemolyticus NAD+ dependent deacetylase, regulates host response during infection by induction of histone deacetylation

Here we report V. parahaemolyticus (serotype O3:K6) infection induced histone deacetylation in intestinal epithelial cells, wherein we have shown deacetylation of H3K9, H3K56, H3K18 and H4K16 residues. Interestingly we observed concomitant downregulation of host deacetylases. Overall design: Response to Infection at two different bacterial loads