Creatine mediated crosstalk between adipocytes and cancer cells regulates obesity-driven breast cancer

Obesity is a major risk factor for adverse outcomes in breast cancer. Maguire, Ackerman et al. reveal Gatm and Acsbg1 as molecular regulators of obesity-driven breast cancer progression. They further show that in obesity creatine is a key metabolite in the crosstalk between adipocytes and breast tumors. Examining 4th mammary subcutaneous adiose tissue in lean and obese mice, near and far from the breast tumor