Analysis of Bone Morphogenetic Protein 15 (BMP15)-induced transcriptome in human granulosa cells for the identification of novel candidate genes for Primary Ovarian Insufficiency. Analysis of Bone Morphogenetic Protein 15 (BMP15)-induced transcriptome in human granulosa cells for the identification of novel candidate genes for Primary Ovarian Insufficiency

Analysis of primary cultures of human granulosa cells (hGCs) stimulated with recombinant human BMP15 (rhBMP15) at gene expression level. The hypothesis tested in the present study was that rhBMP15 regulates genes and processes of maturation and differenti Overall design: Total RNA obtained from primary cultures of hGCs stimulated with rhBMP15 for 2 and 6 hours compared to Not-stimulated control hGCs.