Crystal structure of mature apo-Cathepsin L C25A mutant in complex with Gln-Leu-Ala peptide

Crystal structure of mature apo-Cathepsin L C25A mutant in complex with Gln-Leu-Ala peptide Descriptor: 2-acetamido-2-deoxy-alpha-D-glucopyranose-(1-6)-beta-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-2)]alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-alpha-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, Cathepsin L1, ... Authors: Adams-Cioaba, M.A, Krupa, J.C, Mort, J.S, Bountra, C, Weigelt, J, Arrowsmith, C.H, Edwards, A.M, Bochkarev, A, Min, J, Structural Genomics Consortium (SGC) Deposit date: 2009-09-29 Release date: 2010-03-23 Last modified: 2024-10-16 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Structural basis for the recognition and cleavage of histone H3 by cathepsin L. Nat Commun, 2, 2011

成熟无配体组织蛋白酶L（Cathepsin L）C25A突变体与谷氨酰胺-亮氨酸-丙氨酸（Gln-Leu-Ala）肽复合物的晶体结构。描述：2-乙酰氨基-2-脱氧-α-D-吡喃葡萄糖-(1→6)-β-D-吡喃甘露糖-(1→6)-[α-D-吡喃甘露糖-(1→2)]α-D-吡喃甘露糖-(1→4)-2-乙酰氨基-2-脱氧-α-D-吡喃葡萄糖-(1→4)-2-乙酰氨基-2-脱氧-β-D-吡喃葡萄糖、2-乙酰氨基-2-脱氧-β-D-吡喃葡萄糖；涉及蛋白为组织蛋白酶L1（Cathepsin L1）……。作者：Adams-Cioaba, M.A.、Krupa, J.C.、Mort, J.S.、Bountra, C.、Weigelt, J.、Arrowsmith, C.H.、Edwards, A.M.、Bochkarev, A.、Min, J.；所属机构：结构基因组学联盟（Structural Genomics Consortium, SGC）。提交日期：2009-09-29；发布日期：2010-03-23；最后修改日期：2024-10-16。实验方法：X射线衍射（X-RAY DIFFRACTION），分辨率2.5 Å。引用文献：《组织蛋白酶L识别并切割组蛋白H3的结构基础》，发表于《自然·通讯》（Nat Commun），2011年，第2卷。