The MLL3/GRHL2 complex regulates early malignant transformation and anti-tumor immunity in squamous cancer

NIAID Data Ecosystem2026-05-02 收录

鳞状细胞癌早期恶性转化

抗肿瘤机制

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https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE238119 数据链接链接失效反馈

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This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

创建时间：

2024-07-20

Targeting CPT1A triggers cGAS/STING activation to engage neutrophils for tumor elimination

肿瘤免疫治疗

抗肿瘤机制

Lipid metabolism plays an important role in tumor progression and immune evasion. Targeting fatty acid oxidation (FAO) has been shown to be a promising approach to treat cancers. However, the impact o

NIAID Data Ecosystem70

Table_2_Transcriptome profiling of A549 non-small cell lung cancer cells in response to Trichinella spiralis muscle larvae excretory/secretory products.XLSX

抗肿瘤机制

肿瘤代谢重编程

Trichinella spiralis (T. spiralis) muscle-larva excretory/secretory products (ML-ESPs) is a complex array of proteins with antitumor activity. We previously demonstrated that ML-ESPs inhibit the proli

NIAID Data Ecosystem40

Irinotecan activates anti-tumor immunity in HCT116 tumor cells

抗肿瘤机制

药物转录组学

Topoisomerase I (Top1) is a classical drug target for anticancer therapy, but its role in immune signaling in cancer cells remain unclear. Here, we aimed to explore the possible role and mechanism of

NIAID Data Ecosystem30

Antioxidant metabolism in activated CD8+ T cells regulates stem-like human memory T cell formation and anti-tumor immunity. Antioxidant metabolism in activated CD8+ T cells regulates stem-like human memory T cell formation and anti-tumor immunity

免疫疗法优化

抗肿瘤机制

Adoptive T cell transfer (ACT) immunotherapy benefits from early-differentiated memory stem-like T (TSCM) cells capable to persist in the long term and to generate potent anti-tumor effectors. Due to

NIAID Data Ecosystem40

TIPE2 is a checkpoint in natural killer cell maturation and anti-tumor immunity. TIPE2 is a checkpoint in natural killer cell maturation and anti-tumor immunity

NK细胞

抗肿瘤机制

The maturation process determines NK cell functionality. We verified that tumor necrosis factor-alpha-induced protein-8 like-2 (TIPE2) works as a potent negative regulator in NK cell maturation. We fo

NIAID Data Ecosystem40

The MLL3/GRHL2 complex regulates early malignant transformation and anti-tumor immunity in squamous cancer

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