Crystal structure of the first bromodomain (BD1) of human BRDT bound to GXH-II-082
收藏Protein Data Bank Japan2023-10-18 更新2026-04-19 收录
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Crystal structure of the first bromodomain (BD1) of human BRDT bound to GXH-II-082 Descriptor: Bromodomain testis-specific protein, N,N'-[(1,16-dioxo-4,7,10,13-tetraoxahexadecane-1,16-diyl)di(piperidine-1,4-diyl)]bis{4-[(4-{4-chloro-3-[(2-methylpropane-2-sulfonyl)amino]anilino}-5-methylpyrimidin-2-yl)amino]-2-fluorobenzamide} Authors: Chan, A, Schonbrunn, E. Deposit date: 2021-05-07 Release date: 2022-05-18 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (1.39 Å) Cite: Bivalent BET Bromodomain Inhibitors Confer Increased Potency and Selectivity for BRDT via Protein Conformational Plasticity. J.Med.Chem., 65, 2022
人BRDT的首个溴结构域（bromodomain, BD1）与GXH-II-082结合的晶体结构
描述项：溴结构域睾丸特异性蛋白（BRDT），N,N'-[(1,16-二氧代-4,7,10,13-四氧杂十六烷-1,16-二基)二(哌啶-1,4-二基)]双{4-[(4-{4-氯-3-[(2-甲基丙烷-2-磺酰基)氨基]苯胺基}-5-甲基嘧啶-2-基)氨基]-2-氟苯甲酰胺}
作者：Chan, A、Schonbrunn, E.
沉积日期：2021-05-07
发布日期：2022-05-18
末次修改日期：2023-10-18
实验方法：X射线衍射（1.39 Å）
引用文献：《双价BET溴结构域抑制剂通过蛋白质构象可塑性增强对BRDT的效力与选择性》，J. Med. Chem., 65, 2022
创建时间：
2021-05-07
