Interaction analysis between 82 lipid ratios and markers of obesity in the Busselton Health Study.

Linear regression analysis was performed between 82 lipid ratios and various markers of obesity, including sex as the interaction term and adjusting for age, in the BHS cohort (n = 4,492). 1Lipid nomenclature is read as follows: letters denote the head group; () brackets denote the sum composition of the lipid measured including total number of carbons and double bonds; [] denote the position of the acyl chain; n3 and n6 denote omega-3 and omega-6 poly-unsaturated fatty acid species; 2SD-change denotes the standard deviation change per unit of waist circumference (WC), body-mass-index (BMI), waist–hip ratio (WHR). 3Interaction p-value denotes whether the associations between each lipid ratio and obesity-marker are statistically different between males and females. 4p-gain was calculated by dividing the lowest p-value among the lipid species used in the ratio by the p-value of the lipid ratio. The p-gain was deemed significant if it exceeded 10 × the number of ratios tested (p-gain >820). (XLSX)