Supplementary material -Pediococcus acidilactici CCFM1344 intervention during pregnancy prevents autism-like behaviors in early-life offspring of maternal high-fat diet

Supplementary material -Pediococcus acidilactici CCFM1344 intervention during pregnancy prevents autism-like behaviors in early-life offspring of maternal high-fat diet
Supplementary Material 1 (Microbiota Data): It allows researchers to identify which specific bacterial taxa are increased or decreased by the HFD and subsequently restored by the probiotic. By correlating these microbial changes with the maternal cytokine and offspring brain/behavior data, one can generate hypotheses about which microbes or microbial functions are most critical for the protective effects.
Supplementary Material 2 (Gene Expression): This data demonstrates the functional consequences of the maternal interventions on the offspring. The gene expression data (Gfap, Mmp9, Il-1b, Mobp) provides a molecular snapshot of the brain’s state, revealing specific pathways (neuroinflammation, myelination) that are vulnerable to maternal diet.