Chromosome Compartments on the Inactive X Guide TAD Formation Independently of Transcription during X-Reactivation
收藏干细胞与再生医学数据中心2022-02-20 更新2024-03-06 收录
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To investigate the dynamics of X-chromosome reactivation, we differentiated mouse embryonic stem cells (ESCs) into neural precursor cells (NPCs) and later reprogrammed them into induced pluripotent stem cells (iPSCs). During the conversions of NPCs into iPSC, we assessed the kinetics of X-chromosome reactivation. We generated allele-specific RNA-seq datasets to assess gene reactivation dynamics, employed ATAC-seq to investigate chromatin opening dynamics and performed in situ Hi-C to explore dynamics of chromosome structure.
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CRG
创建时间：
2022-02-20
