Sustainability of specific improvements of cardiorespiratory fitness and insulin sensitive metabolism in type 2 diabetes after exercise training

High intensity interval training (HIIT) improves metabolism, but maybe with differences in sustainability between prediabetes and type 2 diabetes (T2D). We hypothesized that HIIT-induced changes are maintained after 4-week detraining in humans with (20 T2D) and without T2D (12 insulin-sensitive, IS-NDM; 10 insulin-resistant, IR-NDM). To explore the change in protein cargo of small extracellular vesicles (SEV), we measured the proteome of SEVs from serum of T2D, IR-NMD and IR-NDM individuals.