Temporal dynamics of the gut microbiota in people sharing a confined environment a 520-day ground-based space simulation MARS500

The MARS500 project the longest ground-based space simulation ever provided us with a unique opportunity to trace the crew microbiota over 520 days of isolated confinement such as that faced by astronauts in real long-term interplanetary space flights and after returning to regular life for a total of 2 years.