IC50 Values for Perampanel Inhibition of AMPA- and Kainate-Evoked Currents.

IC50 values are the concentration of perampanel estimated to inhibit the current response by one-half, as determined by logistic fits to the mean percent of control values as presented in Fig. 1D and E, and Fig. 2B. To assess statistical significance of differences between the IC50 values, the perampanel concentration-response relationship was linearized. The concentration was log transformed and the current response was transformed as logit Y = ln [(Y+ε)/(Ymax – Y+ε)]. Analysis of covariance models were used to estimate IC50 values. Differences among the IC50 values were tested for significance by comparing the response lines against a common response line, estimated without regard to the concentration. A Tukey-Cramer adjustment was used on those post hoc comparisons. NS, not significant.IC50 Values for Perampanel Inhibition of AMPA- and Kainate-Evoked Currents.