Investigation of the Role of Micro-RNAs in the Immunopatho-genesis of Oral Lichen Planus Patients

Background and Objectives: Lichen planus (LP) is a chronic inflammatory disorder affecting the skin, mucous membranes, and other tissues. Its exact etiology remains elusive, but the immunopathogenesis of LP has gained significant attention due to its complex interplay between immune dysregulation and tissue response. We aim to investigate the importance of understanding LP immunopathogenesis, explicitly focusing on the role of microRNAs (miRNAs) in modulating the disease process. Materials and Methods: In our research, punch biopsy samples were collected from 85 patients, including 52 Oral Lichen Planus (OLP) and 33 healthy volunteer patients, according to specific inclusion and exclusion criteria. Samples were analyzed for miR-21, p53, and p63 expression using real-time Polymerase Chain Reaction (RT/PCR). Results: The OLP group was compared to a control group, revealing increased miR-21 and p53 expression.
Further comparison of the OLP group’s miR-21, p53, and p63 expression showed a weak positive correlation between p53 and miR-21 and a weak negative correlation between p63 and miR-21. These findings suggest that miR-21 and its potential targets, p53 and p63, play crucial roles in the pathogenesis and malignant potential of OLP. Conclusions: In conclusion, our research suggests that miR-21 and its target genes p53 and p63 are crucial in the molecular pathogenesis and cancerous potential of OLP. This understanding can lead to targeted treatment approaches for this pre-cancerous condition.