Effective population sizes of a major vector of human diseases, Aedes aegypti

The effective population size (Ne) is a fundamental parameter in population genetics that determines the relative strength of selection and random genetic drift, the effect of migration, levels of inbreeding, and linkage disequilibrium. In many cases where it has been estimated in animals, Ne is on the order of 10-20% of the census size. In this study, we use 12 microsatellite markers and 14,888 single nucleotide polymorphisms (SNPs) to empirically estimate Ne in Aedes aegypti, the major vector of yellow fever, dengue, chikungunya, and Zika viruses. We used the method of temporal sampling to estimate Ne on a global dataset made up of 46 samples of Ae. aegypti that included multiple time points from 17 widely distributed geographic localities. Our Ne estimates for Ae. aegypti fell within a broad range (~25-3,000), and averaged between 400 and 600 across all localities and time points sampled. Adult census size (Nc) estimates for this species range between one and five thousand, so the Ne...有效种群大小（Ne）是种群遗传学的基础参数，其决定了选择与随机遗传漂变的相对强度、迁移效应、近交水平以及连锁不平衡状态。在已开展的诸多动物种群Ne估算研究中，Ne通常约为种群普查数量的10%~20%。本研究利用12个微卫星标记与14888个单核苷酸多态性（SNPs）位点，对黄热病、登革热、基孔肯雅热及寨卡病毒的主要传播媒介埃及伊蚊（Aedes aegypti）的Ne进行实证估算。我们采用时间采样法，基于涵盖17个广泛分布地理点位、多个时间点的46份埃及伊蚊样本构建全球数据集，以此开展Ne估算。本次研究得到的埃及伊蚊Ne估算值分布于约25至3000的宽泛区间内，所有采样点位与时间点的平均Ne介于400至600之间。该物种的成虫普查数量（Nc）估算值介于1000至5000之间，因此Ne...