SeaBase

Marine and aquatic animals are extraordinarily useful as models for identifying mechanisms of development and evolution, regeneration, resistance to cancer, longevity and symbiosis, among many other areas of research. This is due to the great diversity of these organisms and their wide-ranging capabilities. Genomics tools are essential for taking advantage of these "free lessons" of nature. However, genomics and transcriptomics are challenging in emerging model systems. Here, we present SeaBase, a tool for helping to meet these needs. Specifically, SeaBase provides a platform for sharing and searching transcriptome data. More importantly, SeaBase will support a growing number of tools for inferring gene network mechanisms. The first dataset available on SeaBase is a developmental transcriptomic profile of the sea anemone Nematostella vectensis (Anthozoa, Cnidaria). Additional datasets are currently being prepared and we are aiming to expand SeaBase to include user-supplied data for any number of marine and aquatic organisms, thereby supporting many potentially new models for gene network studies海洋与水生动物作为研究模型，在解析发育与进化、再生、抗癌机制、寿命调控以及共生关系等诸多研究领域中具备极高的应用价值。这源于该类生物的丰富多样性与广泛的功能特性。若要充分借助大自然赋予的这类天然研究范本，基因组学（Genomics）工具不可或缺。然而，针对新兴研究模型开展基因组学与转录组学（Transcriptomics）研究仍面临诸多挑战。为此，本文提出SeaBase这一工具以满足上述需求。具体而言，SeaBase提供了一个用于共享与检索转录组（Transcriptome）数据的平台。更为重要的是，SeaBase将逐步支持一系列用于推断基因网络（Gene network）调控机制的分析工具。SeaBase已上线的首个数据集是海葵*Nematostella vectensis*（刺胞动物门Cnidaria，珊瑚纲Anthozoa）的发育转录组图谱。目前尚有更多数据集正在筹备中，我们计划进一步拓展SeaBase的覆盖范围，使其支持用户上传任意海洋与水生生物的相关数据，从而为更多潜在的基因网络研究新模型提供支撑。

搜集汇总

背景与挑战

背景概述

SeaBase是一个专为海洋和水生生物设计的转录组数据共享与搜索平台。它支持基因网络机制推断工具，并以海葵Nematostella vectensis的发育转录组数据作为首个可用数据集，旨在扩展以容纳更多用户提供的数据。