Expression profile of stromal vascular fraction during would healing. Expression profile of stromal vascular fraction during would healing

Stromal cells rapidly reorganize cell composition during would healing. Resident stromal cells secrete systemic ligands and mobilize immune cells from bone marrow. Subsequently resident cells and mobilized immune cells cooperate together for efficient wound healing. We term such phenomena as "stromal priming for wound healing" and investigated the intercellular communications among heterogeneous populations through comrehensive expression analysis. Overall design: Subcutaneous fat was surgically injured and stromal vascular fraction was purified during healing process. Total RNA from day zero, one or three after injury was purified and expression profile was investigated by Affimetrix microarray.