Gene expression in the F1 and F2 mouse hippocampus with intrauterine hyperglycemia exposure

Studies on human and animals suggest associations between gestational diabetes mellitus (GDM) with impaired cognitive performance in offspring. Using a mouse model of diabetes during pregnancy, we found that intrauterine hyperglycemia exposure resulted in memory impairment in both the first filial (F1) males and the second filial (F2) males from the F1 male offspring. The effects of intrauterine hyperglycemia exposure on F1 and F2 hippocampus gene expression were also examined. Hippocampus, male, 16 weeks old. Three groups, F1 offsprings of GDM (F1-GDM) ，F2 offsprings of GDM (F2-GDM) and Control, with 5 replicates per group.