Data for: Probing the architecture, dynamics, and inhibition of the PI4KIIIA/TTC7/FAM126 complex

Table S1A. All hydrogen deuterium exchange (HDX) peptide data for experiments examining the global exchange of PI4KIIIA, TTC7B, and FAM126A. The charge state (Z), residue start, residue end number, retention time (RT) and sequence are displayed for every peptide. In the Raw Data column, the two time points (0.3s and full) are labelled, and the relative level of HDX is coloured according to the amount of deuterium incorporated, on a blue to red continuum. The data listed for the 0.3s time point are the average of three independent experiments, with SD shown next to all HDX values. In the Normalized to Full Deuteration column, the 0.3s data has been normalised to the full deuteration measurements with the exception of those data (surrounded by black lines) where the full deuteration measurement was lower than 20% deuterium incorporation. The third column denotes the corresponding peptide centroid. Table S1B. All HDX peptide data for experiments examining the complex dynamics of PI4KIIIA, TTC7B, and FAM126A. The charge state (Z), residue start, residue end number, retention time (RT) and sequence are displayed for every peptide. The two columns represent each state examined (+/- PI4KIIIA) and contain the data for five time points. The data listed are the average of three independent experiments, with SD shown next to all HDX values. Table S1C. All HDX peptide data for experiments examining the dynamics of inhibitor specificity of PI4KIIIA, TTC7B, and FAM126A. The charge state (Z), residue start, residue end number, retention time (RT) and sequence are displayed for every peptide. The three columns represent each state examined (+/- inhibitor) and contain the data for four time points. The data listed are the average of three independent experiments, with SD shown next to all HDX values.表S1A。本数据集收录了用于探究PI4KIIIA、TTC7B与FAM126A全局氢氘交换（hydrogen deuterium exchange, HDX）实验的全部肽段数据。每条肽段均标注了电荷态（Z）、残基起始位点、残基终止位点、保留时间（retention time, RT）与氨基酸序列。在“原始数据”列中，标注了两个时间点（0.3s与完全氘代状态），HDX相对水平以蓝-红渐变光谱依据氘掺入量的多少进行着色。0.3s时间点的数据为三次独立实验的平均值，所有HDX数值旁均标注了标准差（standard deviation, SD）。在“归一化至完全氘代”列中，0.3s数据已完成归一化处理，仅排除了被黑线框选的数据——这类数据对应的完全氘代测量的氘掺入量低于20%。第三列标注了对应肽段的质心峰。 表S1B。本数据集收录了用于探究PI4KIIIA、TTC7B与FAM126A复合物动态变化实验的全部HDX肽段数据。每条肽段均标注了电荷态（Z）、残基起始位点、残基终止位点、保留时间（RT）与氨基酸序列。本数据集包含两列数据，分别对应所检测的两种状态（±PI4KIIIA），并收录了五个时间点的实验数据。所有数据均为三次独立实验的平均值，所有HDX数值旁均标注了SD。 表S1C。本数据集收录了用于探究PI4KIIIA、TTC7B与FAM126A抑制剂特异性动态变化实验的全部HDX肽段数据。每条肽段均标注了电荷态（Z）、残基起始位点、残基终止位点、保留时间（RT）与氨基酸序列。本数据集包含三列数据，分别对应所检测的三种状态（±抑制剂），并收录了四个时间点的实验数据。所有数据均为三次独立实验的平均值，所有HDX数值旁均标注了SD。