Rapid reprogramming of epigenetic and transcriptional profiles in mammalian culture systems

ChEBI2014-12-17 更新2026-07-21 收录

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哺乳动物细胞培养模型

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https://www.ebi.ac.uk/biostudies/ArrayExpress/studies/E-MTAB-3172 数据链接链接失效反馈

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Rapid reprogramming of epigenetic and transcriptional profiles in mammalian culture systems

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2014-12-17

Epigenetic Profiles Signify Cell Fate Plasticity in Unipotent Spermatogonial Stem and Progenitor Cells (RNA-Seq). Mus musculus

精原干细胞多能性转化

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Mammalian spermatogonial stem cells (SSCs) spontaneously convert to multipotent adult spermatogonial-derived stem cells (MASCs) during in vitro expansion. Here, we examine the epigenetic signature of

NIAID Data Ecosystem90

Active and Passive Demethylation of Male and Female Pronuclear DNA in the Mammalian Zygote

受精卵DNA去甲基化

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The epigenomes of mammalian sperm and oocytes, characterized by gamete-specific 5-methylcytosine (5mC) patterns, are reprogrammed during early embryogenesis to establish full developmental potential.

NIAID Data Ecosystem50

Epigenetic reprogramming enables the primordial germ cell-to-gonocyte transition (AbaSeq)

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原始生殖细胞

Gametes are highly specialised cells that can give rise to the next generation through their ability to generate a totipotent zygote. In mouse, germ cells are first specified in the developing embryo

NIAID Data Ecosystem30

Ago1 controls myogenic differentiation by regulating eRNA mediated CBP guided epigenome reprogramming

肌肉分化调控

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The role of Argonaute (Ago) proteins in post-transcriptional gene silencing in the cytoplasm is well characterized. However, its nuclear function still remains elusive. In this work, we investigated t

NIAID Data Ecosystem50

HIF-1 directly induces TET3 expression to redistribute 5-hydroxymethylcytosine and induce erythroid gene expression in hypoxia [RNA-seq]. HIF-1 directly induces TET3 expression to redistribute 5-hydroxymethylcytosine and induce erythroid gene expression in hypoxia [RNA-seq]

红细胞生成低氧应答

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We performed RNA-sequencing on erythropoietic cells cultured in normoxia or hypoxia at days 3,7, and 10. We found numerous expression changes induced by hypoxia, including the canonical hypoxia target

NIAID Data Ecosystem40

Rapid reprogramming of epigenetic and transcriptional profiles in mammalian culture systems

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