Catalytic Direct β‑Arylation of Simple Ketones with Aryl Iodides
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https://figshare.com/articles/dataset/Catalytic_Direct_Arylation_of_Simple_Ketones_with_Aryl_Iodides/2349223
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Herein we report a direct β-arylation of simple ketones with widely available aryl iodides, combining palladium-catalyzed ketone oxidation, aryl-halide activation, and conjugate addition through a single catalytic cycle. Simple cyclic ketones with different ring-sizes, as well as acyclic ketones, can be directly arylated at the β-position with complete site-selectivity and excellent functional group tolerance.
创建时间:
2016-02-18



