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Methylomes of wild-type and MeCP2 knockout brain cells

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NIAID Data Ecosystem2026-03-10 收录
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By performing whole genome methylome analysis in MeCP2 knock-out mice brain, we identify both hypo- and hypermethylated regions overlapping with MeCP2 binding sites. Hypermethylation was mainly observed at CpG promoters, suggesting that MeCP2 contributes to the protection of these regions from methylation in brain. Overall design: Whole genome bisulfite sequencing profiles were generated for wild type and MeCP2 KO cells, 1 replicate each.

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2019-01-30
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