Efficient method for the differentiation of human pluripotent stem cells (hPSCs) into functional brain microvascular endothelial (BME)-like cells
收藏干细胞与再生医学数据中心2022-02-20 更新2024-03-06 收录
下载链接：
http://data.iscr.ac.cn/Article?id=69cb7be75ed4f9f4ea1699622efba93d
下载链接
链接失效反馈官方服务：
资源简介：
We developed an efficient method for the differentiation of human pluripotent stem cells (hPSCs) into functional brain microvascular endothelial (BME)-like cells. Here, we compared the whole-gene expression pattern of BME-like cells differentiated from hPSCs with primary BMECs (pBMECs). Comparison of expressed genes in the purified BME-like cells and pBMECs indicated a high degree of similarity. Furthermore, brain ECs related gene, including BBB membrane specific proteins, transporters, and channels, showed similar levels between BME-like cells and pBMECs. This study reveals that hPSC-derived BME-like cells have similar character with pBMECs.
提供机构：
KRIBB
创建时间：
2022-02-20
