Structure of the avibactam-CDD-1 120 minute complex in imidazole and MPD

Structure of the avibactam-CDD-1 120 minute complex in imidazole and MPD Descriptor: (2S,5R)-1-formyl-5-[(sulfooxy)amino]piperidine-2-carboxamide, (4S)-2-METHYL-2,4-PENTANEDIOL, Beta-lactamase, ... Authors: Smith, C.A, Vakulenko, S.B, Stewart, N.K. Deposit date: 2021-02-08 Release date: 2021-05-12 Last modified: 2024-10-23 Method: X-RAY DIFFRACTION (1.83 Å) Cite: In Crystallo Time-Resolved Interaction of the Clostridioides difficile CDD-1 enzyme with Avibactam Provides New Insights into the Catalytic Mechanism of Class D beta-lactamases. Acs Infect Dis., 7, 2021

本数据集为咪唑与MPD（2-甲基-2,4-戊二醇，2-Methyl-2,4-Pentanediol）体系中阿维巴坦（avibactam）与CDD-1孵育120分钟所得复合物的晶体结构。
描述物：(2S,5R)-1-甲酰基-5-(磺酰氧基氨基)哌啶-2-甲酰胺、(4S)-2-甲基-2,4-戊二醇、β-内酰胺酶（Beta-lactamase）等。
作者：Smith, C.A、Vakulenko, S.B、Stewart, N.K.
提交日期：2021-02-08
发布日期：2021-05-12
最后修改日期：2024-10-23
测试方法：X射线衍射（X-RAY DIFFRACTION，分辨率1.83 Å）
引用文献：《In Crystallo 下艰难梭菌（Clostridioides difficile）CDD-1酶与阿维巴坦的时间分辨相互作用为D类β-内酰胺酶的催化机制提供新见解》，发表于《ACS Infectious Diseases》2021年第7卷。