A Study of Unilateral Retinoblastoma With and Without Histopathologic High-Risk Features and the Role of Adjuvant Chemotherapy

This phase III trial is studying vincristine, carboplatin, and etoposide to see how well they
work compared to observation only in treating patients who have undergone surgery for newly
diagnosed retinoblastoma. Drugs used in chemotherapy, such as vincristine, carboplatin, and
etoposide, work in different ways to stop the growth of tumor cells, either by killing the
cells or by stopping them from dividing. Giving more than one drug (combination chemotherapy)
after surgery may kill any tumor cells that remain after surgery. Sometimes, after surgery,
no additional treatment is needed for the tumor until it progresses. In this case,
observation may be sufficient.