Polygalaxanthone III, an anti-inflammatory ingredient in Polygala japonica Houtt. repaired the Malassezia - stimulated Skin Injury via STAT3 phosphorylated activation

Malassezia are commensal and lipid-dependent yeasts in human skin, but they also have a pathogenic lifestyle associated with several common skin disorders, such as atopic dermatitis, eczema and so on. Symptoms include red, itchy, and inflamed skin. We studied the growth characteristics and biochemical analyses of M.furfur, which showed that the protein contents were greater in 24h extracts, then used them to infect C57BL/6 mouse resulting skin rupture. Polygalaxanthone III (POL), a more effective anti-inflammatory ingredient in Polygala japonica Houtt., was applied externally to the ulceration and achieved wounds heal quickly. POL could not inhibit Malassezia action tested by the inhibition zone test, but affected the lipid droplets formation in HaCaT cells. The wound healed molecular mechanisms may involve in STAT3 pathway according to the Weston Blotting results of skin tissues. Malassezia’s role in skin health is far from certain and there's no clean solution, so to understand Malassezia associated skin diseases development in general and sought for solutions is very important.